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FoCoSi - Follicular-like Conjunctivitis associated with Siliconhydrogels

  • Abstract 1.1 Purpose The purpose of this study is to prescribe follicular-like conjunctivitis associated with Siliconhydrogels (FoCoSi) in silicone hydrogel contact lens wearers as a novel subtype of the well prescribed contact lens induced papillary conjunctivitis (CLPC). 1.2 Methods 1211 patients who wore silicon hydrogels were included in this prospective, nonrandomised, single center study. Subjective symptoms and clinical signs were evaluated for daily wear (DW) and continuous wear (CW) populations for several (Lotrafilcon A, Lotrafilcon B, Senofilcon A, Galyfilcon A) silicon hydrogel lens types. CCLRU and other specifically developed grading scale were utilized for evaluation. Grading of 2 and above was rated as clinically significant. Statistical evaluation was performed for eyes rather than subjects. 1.3 Results The clinical presentation of FoCoSi could be confirmed and showed an incidence of 3.8%. Lotrafilcon A followed by Senofilcon A on a CW modality presented, with a risk ratio of 2.49 and 1.53 respectively, the highest affinity for developing FoCoSi. Fluorescein positive spots showed the closest correlation with subjective symptoms reported by patients and divided FoCoSi into an active and dormant form. Besides Protein, Lipid deposition on the contact lens surface and air pollution like Ozone or fine and ultrafine particles seems to be important factors in developing FoCoSi, whereas mechanical irritation played a minor role. 1.4 Conclusion FoCoSi is a novel and relevant subtype of CLPC. Further studies should be performed to validate these findings and clear up several questions about the aetiology of FoCoSi and CLPC. Keywords: Giant papillary conjunctivitis (GPC), contact lens-induced papillary conjunctivitis (CLPC), follicular-like conjunctivitis associated with siliconhydrogels (FoCoSi)

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Author:Michael Wyss
Advisor:Michael Bärtschi, Dietmar Kümmel
Document Type:Master's Thesis
Date of Publication (online):2015/12/16
Publishing Institution:Hochschule Aalen
Granting Institution:Hochschule Aalen, Optik und Mechatronik
Date of final exam:2008/07/01
Release Date:2016/01/13
Tag:contact lens-induced papillary conjuctivitis CLPC; follicular-like conjunctivitis associated with siliconhydrogels FoCoSi; giant papillary conjuctivitis GPC
GND Keyword:Kontaktlinse; Studie
Open Access:Open Access
Licence (German):License LogoVeröffentlichungsvertrag für Publikationen mit Print on Demand