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Young but not Naive: Leaders of Tomorrow Expect Limits to Digital Freedom to Preserve Freedom
(2021)
What does it matter for trust of green consumers? An application to German electricity market
(2020)
WAR FOR TALENTS MEETS FACIAL EXPRESSION - leveraging recruiting videos in professional service firms
(2020)
VR-EvoEA+BP
(2023)
Enterprise digitalization results in an evolving and dynamic IT landscape of digital elements, relations, knowledge, content, activities, and business processes (BPs), which are spread across disparate enterprise IT systems, repositories, and tools. To be relevant, useful, and actionable, Enterprise Architecture (EA) relies on comprehensive documentation based on underlying information corresponding to reality. Yet current diagram-centric 2D visualizations for EA and BP models are too limited in scope to express reality (intentionally simplifying), are typically static (and not kept up-to-date), and cannot express and integrate the changing complexities of the enterprise context. This misalignment with reality and a changing enterprise misinforms and constrains the context-awareness and perception of EA and BP for stakeholders, impeding analyses, management, and holistic insights into the enterprise digital reality. This paper contributes our nexus-based Virtual Reality (VR) solution concept VR-EvoEA+BP to support comprehensive enterprise context visualization in conjunction with EA and model evolution and BP mining and analysis. Portraying an organic, evolving, and dynamic enterprise while supplementing static enterprise structure depictions, our implementation demonstrates its feasibility. A case study based on enterprise analysis and BP scenarios exhibits its potential.
VR Live Motion Capture
(2021)
Virtuous cycles
(2019)
Drugs containing amine groups react with CO2 to form crystalline ammonium carbamates or carbamic acids. In this approach, both the cation and anion of the salt, or the neutral CO2 adduct, are derived from the parent drug, generating new crystalline versions in a 'masked' or prodrug form. It is proposed that this approach may serve as a valuable new tool in engineering the physical properties of drugs for formulation purposes.
Two-Level Classification of Chronic Stress Using Machine Learning on Resting-State EEG Recordings
(2020)
Taar1 is a G protein-coupled receptor (GPCR) confined to primary cilia of rodent thyroid epithelial cells. Taar1-deficient mouse thyroid follicles feature luminal accumulation of thyroglobulin suggesting that Taar1 acts as a regulator of extra- and pericellular thyroglobulin processing, which is mediated by cysteine cathepsin proteases present at the apical plasma membrane of rodent thyrocytes. Here, by immunostaining and confocal laser scanning microscopy, we demonstrated co-localization of cathepsin L, but only little cathepsin B, with Taar1 at primary cilia of rat thyrocytes, the FRT cells. Because proteases were shown to affect half-lives of certain receptors, we determined the effect of cathepsin activity inhibition on sub-cellular localization of Taar1 in FRT cells, whereupon Taar1 localization altered such that it was retained in compartments of the secretory pathway. Since the same effect on Taar1 localization was observed in both cathepsin B and L inhibitor-treated cells, the interaction of cathepsin activities and sub-cellular localization of Taar1 was thought to be indirect. Indeed, we observed that cathepsin inhibition resulted in a lack of primary cilia from FRT cells. Next, we proved that primary cilia are a necessity for Taar1 trafficking to reach the plasma membrane of FRT cells, since the disruption of primary cilia by treatment with β-cyclodextrin resulted in Taar1 retention in compartments of the secretory pathway. Furthermore, in less well-polarized rat thyrocytes, namely in FRTL-5 cells lacking primary cilia, Taar1 was mainly confined to the compartments of the secretory pathway. We conclude that Taar1 localization in polarized thyroid epithelial cells requires the presence of primary cilia, which is dependent on the proteolytic activity of cysteine cathepsins B and L.
As the size of software program code bases in software development projects increases, insight into and comprehension of their underlying dependency structures presents a challenge for programmers. The increasing availability of virtual reality (VR) systems brings VR-based visualization of program code structures into practical reach for software developers and could support program comprehension and insight. However, the complete visual immersion with VR presents a cognitive burden and potential distractions. Applying gamification to such a VR visualization capability has hitherto been insufficiently investigated as to its potential motivation and program comprehension factors. This paper describes and evaluates a VR digital gamification approach for program code called VR Gamified Immersion in Software structures (VR-GaImS), which applies digital gamification to a multi-metaphor VR visualization of software program structures. The results of a preliminary empirical investigation utilizing our prototype indicate its potential to increase enjoyment and motivation, focus attention, and encourage the exploration of software structures.