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Zuhörer fesseln
(2019)
Young but not Naive: Leaders of Tomorrow Expect Limits to Digital Freedom to Preserve Freedom
(2021)
Wiener Blut
(2018)
Wie werden wir digital?
(2020)
What does it matter for trust of green consumers? An application to German electricity market
(2020)
WAR FOR TALENTS MEETS FACIAL EXPRESSION - leveraging recruiting videos in professional service firms
(2020)
VR-V&V
(2023)
To build quality into a software (SW) system necessitates supporting quality-related lifecycle activities during the software development. In software engineering, software Verification and Validation (V&V) processes constitute an inherent part of Software Quality Assurance (SQA) processes. A subset of the V&V activities involved are: 1) bidirectional traceability analysis of requirements to design model elements, and 2) software testing. Yet the complex nature of large SW systems and the dependencies involved in both design models and testing present a challenge to current V&V tools and methods regarding support for trace analysis. One of software’s essential challenges remains its invisibility, which also affects V&V activities. This paper contributes VR-V&V, a Virtual Reality (VR) solution concept towards supporting immersive V&V activities. By visualizing requirements, models, and testing artifacts with dependencies and trace relations immersively, they are intuitively accessible to a larger stakeholder audience such as SQA personnel while supporting digital cognition. Our prototype realization shows the feasibility of supporting immersive bidirectional traceability as well as immersive software test coverage and analysis. The evaluation results are based on a case study demonstrating its capabilities, in particular traceability support was performed with ReqIF, ArchiMate models, test results, test coverage, and test source to test target dependencies.
VR-SysML+Traceability
(2023)
As systems grow in complexity, the interdisciplinary nature of systems engineering makes the visualization and comprehension of the underlying system models challenging for the various stakeholders. This, in turn, can affect validation and realization correctness. Furthermore, stakeholder collaboration is often hindered due to the lack of a common medium to access and convey these models, which are often partitioned across multiple 2D diagrams. This paper contributes VR-SysML, a solution concept for visualizing and interacting with Systems Modeling Language (SysML) models in Virtual Reality (VR). Our prototype realization shows its feasibility, and our evaluation results based on a case study shows its support for the various SysML diagram types in VR, cross-diagram element recognition via our Backplane Followers concept, and depicting further related (SysML and non-SysML) models side-by-side in VR.
VR-GitCity
(2023)
The increasing demand for software functionality necessitates an increasing amount of program source code that is retained and managed in version control systems, such as Git. As the number, size, and complexity of Git repositories increases, so does the number of collaborating developers, maintainers, and other stakeholders over a repository’s lifetime. In particular, visual limitations of command line or two- dimensional graphical Git tooling can hamper repository comprehension, analysis, and collaboration across one or multiple repositories when a larger stakeholder spectrum is involved. This is especially true for depicting repository evolution over time. This paper contributes VR-GitCity, a Virtual Reality (VR) solution concept for visualizing and interacting with Git repositories in VR. The evolution of the code base is depicted via a 3D treemap utilizing a city metaphor, while the commit history is visualized as vertical planes. Our prototype realization shows its feasibility, and our evaluation results based on a case study show its depiction, comprehension, analysis, and collaboration capabilities for evolution, branch, commit, and multi-repository analysis scenarios.
Vom Sammler zum Jäger
(2019)
Virtuous cycles
(2019)
Veränderung der Aufgaben von Controller durch SSBI – Ergebnisse einer empirischen Untersuchung
(2021)
Today’s Industry 4.0 Smart Factories involve complicated and highly automated processes. Nevertheless, certain crucial activities such as machine maintenance remain that require human involvement. For such activities, many factors have to be taken into account, like worker safety or worker qualification. This adds to the complexity of selection and assignment of optimal human resources to the processes and overall coordination. Contemporary Business Process Management (BPM) Systems only provide limited facilities regarding activity resource assignment. To overcome these, this contribution pro- poses a BPM-integrated approach that applies fuzzy sets and rule processing for activity assignment. Our findings suggest that our approach has the potential for improved work distribution and cost savings for Industry 4.0 production processes. Furthermore, the scalability of the approach provides efficient performance even with a large number of concurrent activity assignment requests and can be applied to complex production scenarios with minimal effort.
Drugs containing amine groups react with CO2 to form crystalline ammonium carbamates or carbamic acids. In this approach, both the cation and anion of the salt, or the neutral CO2 adduct, are derived from the parent drug, generating new crystalline versions in a 'masked' or prodrug form. It is proposed that this approach may serve as a valuable new tool in engineering the physical properties of drugs for formulation purposes.
Identification and quantitative segmentation of individual blood vessels in mice visualized with preclinical imaging techniques is a tedious, manual or semiautomated task that can require weeks of reviewing hundreds of levels of individual data sets. Preclinical imaging, such as micro-magnetic resonance imaging (μMRI) can produce tomographic datasets of murine vasculature across length scales and organs, which is of outmost importance to study tumor progression, angiogenesis, or vascular risk factors for diseases such as Alzheimer’s. Training a neural network capable of accurate segmentation results requires a sufficiently large amount of labelled data, which takes a long time to compile. Recently, several reasonably automated approaches have emerged in the preclinical context but still require significant manual input and are less accurate than the deep learning approach presented in this paper—quantified by the Dice score. In this work, the implementation of a shallow, three-dimensional U-Net architecture for the segmentation of vessels in murine brains is presented, which is (1) open-source, (2) can be achieved with a small dataset (in this work only 8 μMRI imaging stacks of mouse brains were available), and (3) requires only a small subset of labelled training data. The presented model is evaluated together with two post-processing methodologies using a cross-validation, which results in an average Dice score of 61.34% in its best setup. The results show, that the methodology is able to detect blood vessels faster and more reliably compared to state-of-the-art vesselness filters with an average Dice score of 43.88% for the used dataset.
Taar1 is a G protein-coupled receptor (GPCR) confined to primary cilia of rodent thyroid epithelial cells. Taar1-deficient mouse thyroid follicles feature luminal accumulation of thyroglobulin suggesting that Taar1 acts as a regulator of extra- and pericellular thyroglobulin processing, which is mediated by cysteine cathepsin proteases present at the apical plasma membrane of rodent thyrocytes. Here, by immunostaining and confocal laser scanning microscopy, we demonstrated co-localization of cathepsin L, but only little cathepsin B, with Taar1 at primary cilia of rat thyrocytes, the FRT cells. Because proteases were shown to affect half-lives of certain receptors, we determined the effect of cathepsin activity inhibition on sub-cellular localization of Taar1 in FRT cells, whereupon Taar1 localization altered such that it was retained in compartments of the secretory pathway. Since the same effect on Taar1 localization was observed in both cathepsin B and L inhibitor-treated cells, the interaction of cathepsin activities and sub-cellular localization of Taar1 was thought to be indirect. Indeed, we observed that cathepsin inhibition resulted in a lack of primary cilia from FRT cells. Next, we proved that primary cilia are a necessity for Taar1 trafficking to reach the plasma membrane of FRT cells, since the disruption of primary cilia by treatment with β-cyclodextrin resulted in Taar1 retention in compartments of the secretory pathway. Furthermore, in less well-polarized rat thyrocytes, namely in FRTL-5 cells lacking primary cilia, Taar1 was mainly confined to the compartments of the secretory pathway. We conclude that Taar1 localization in polarized thyroid epithelial cells requires the presence of primary cilia, which is dependent on the proteolytic activity of cysteine cathepsins B and L.