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Institute
Redemanuskript zum Impulsvortrag für die Podiumsdiskussion „Dürfen Maschinen denken (können)?“ auf dem 102. Katholikentag am 28.05.2022 in Stuttgart. Podium: Winfried Kretschmann (MdL, MPräs Baden-Württemberg, Stuttgart), Ursula Nothelle-Wildfeuer (Freiburg), Michael Resch (Stuttgart), Karsten Wendland (Aalen) Moderation: Stefanie Rentsch (Fulda) Anwältin des Publikums: Verena Neuhausen (Stuttgart) - with English translation -
Entwicklung von Gefüge- und Magneteigenschaften beim direkten Recycling von Fe-Nd-B-Basismagneten
(2021)
Cyber security in family businesses - empirical assessments from the perspective of German SMEs
(2020)
SARS-CoV-2 bestimmt maßgeblich unseren Alltag. Seit einiger Zeit ständiger
Wegbegleiter im öffentlichen Raum und teilweise auch modisches Accessoire: Der Mund-Nasenschutz. In einer aktuellen Mixed-Method-Studie geht das Institut für Unternehmensführung (AAUF) der Hochschule Aalen der privaten Nutzung von Mund-Nasenschutz im öffentlichen Raum (Einzelhandel und ÖPNV) auf den Grund. Dafür wurden im Zeitraum vom 25.05.2020 bis 13.06.2020 insgesamt 2.393 Personen in einer Online-Erhebung befragt und die gewonnenen Erkenntnisse um persönliche Interviews (433 Probanden) und Beobachtungen (691 Probanden) vor diversen Supermärkten und Einkaufszentren im süddeutschen Raum ergänzt.
SARS-CoV-2 bestimmt maßgeblich unseren Alltag. Seit einiger Zeit ständiger Wegbegleiter im öffentlichen Raum und teilweise auch modisches Accessoire: Der Mund-Nasenschutz. Im Rahmen einer Mixed-Method-Studie geht das Aalener Institut für Unternehmensführung (AAUF) der privaten Nutzung von Mund-Nasenschutz im öffentlichen Raum (Einzelhandel und ÖPNV) auf den Grund. Dafür wurden im Zeitraum vom 25.05.2020 bis 13.06.2020 insgesamt 2.393 Personen in einer Online-Erhebung befragt und die gewonnenen Erkenntnisse um persönliche Interviews (433 Probanden) und Beobachtungen (691 Probanden) vor diversen Supermärkten und Einkaufszentren im süddeutschen Raum ergänzt. Dieser Forschungsbericht enthält die Ergebnisse der während des Zeitraums vom 02.06.2020 bis 06.06.2020 durchgeführten Interviews.
SARS-CoV-2 bestimmt maßgeblich unseren Alltag. Seit einiger Zeit ständiger
Wegbegleiter im öffentlichen Raum und teilweise auch modisches Accessoire: Der
Mund-Nasenschutz. In einer aktuellen Mixed-Method-Studie geht Institut für Unternehmensführung (AAUF) der Hochschule Aalen der privaten Nutzung von Mund-
Nasenschutz im öffentlichen Raum (Einzelhandel und ÖPNV) auf den Grund. Dafür wurden im Zeitraum vom 25.05.2020 bis 13.06.2020 insgesamt 2.393 Personen in
einer Online-Erhebung befragt und die gewonnenen Erkenntnisse um Beobachtungen (691 Probanden) vor diversen Supermärkten und Einkaufszentren im süddeutschen Raum und persönliche Interviews (433 Probanden) ergänzt.
Organizational Aspects of Cyber Security in Family Firms – an Empirical Study of German Companies
(2021)
Die vorliegende Untersuchung beschäftigt sich mit der Umsetzung und Implementierung von Compliance-Management in deutschen Unternehmen. Dazu wurden 142 Unternehmen anhand einer elektronischen Umfrage befragt. Der Fragebogen enthält 32 Fragen, diese sind in die drei Abschnitte „allgemeine Unternehmensfragen“, „Fragen zum Compliance Management“ und „demographische Daten“ unterteilt. Die Umfrage fokussiert sich hierbei besonders auf Fragestellungen hinsichtlich der organisatorischen Eingliederung, Funktionsweise, Aufgaben und Instrumente sowie der Bewertung des Compliance-Managements innerhalb der Unternehmen.
Veränderungen der Rolle von Controllern in Großkonzernen – Ergebnisse einer empirischen Erhebung
(2021)
Die vorliegende Studie beschäftigt sich mit der Hygiene-Compliance in Krankenhäusern.
Zur Einhaltung von Regeln der Hände- und Flächendesinfektion wurden hierzu Entscheider von Krankenhäusern in Deutschland, Österreich und der Schweiz befragt.
In der Studie zeigt sich eine starke Sensibilisierung für das Thema Compliance. Hier ist hinzuzufügen, dass die Studie vor der Corona-Pandemie durchgeführt wurde, und
bereits zu diesem Zeitpunkt gab es eine Aufmerksamkeit für das Thema.
Cybercrime im Mittelstand
(2020)
Die Bedrohung durch Cyber-Kriminalität entwickelt sich ständig weiter. Auch die Studie des Aalener Instituts für Unternehmensführung (AAUF) zeigt, dass Cyber-Security ein durchaus Ernst zunehmendes Thema ist, dessen sich die Geschäftsleitung zwingend annehmen sollte, gehören Cyber-Angriffe doch mittlerweile schon zum Alltag vieler Unternehmen.
Adoption of artificial intelligence technologies in German SMEs — Results from an empirical study
(2021)
One Single Click is enough – an Empirical Study on Human Threats in Family Firm Cyber Security
(2021)
Relevance and Adoption of AI technologies in German SMEs – Results from Survey-Based Research
(2021)
The effect of personality and gender on individuals' propensity for corruption and corrupt behavior
(2020)
The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, here we successfully target the monomeric structural ensemble of αSyn and thereby identify novel drug-like small molecules that impact multiple pathogenic processes. Using a surface plasmon resonance high-throughput screen, in which monomeric αSyn is incubated with microchips arrayed with tethered compounds, we identified novel αSyn interacting drug-like compounds. Because these small molecules could impact a variety of αSyn forms present in the ensemble, we tested representative hits for impact on multiple αSyn malfunctions in vitro and in cells including aggregation and perturbation of vesicular dynamics. We thereby identified a compound that inhibits αSyn misfolding and is neuroprotective, multiple compounds that restore phagocytosis impaired by αSyn overexpression, and a compound blocking cellular transmission of αSyn. Our studies demonstrate that drug-like small molecules that interact with native αSyn can impact a variety of its pathological processes. Thus, targeting the intrinsically disordered ensemble of αSyn offers a unique approach to the development of small molecule research tools and therapeutics for Parkinson's disease.
The Dimensional Accuracy of Thin-Walled Parts Manufactured by Laser-Powder Bed Fusion Process
(2020)
Designing a Randomized Trial with an Age Simulation Suit-Representing People with Health Impairments
(2020)
Intelligente Lastkollektivoptimierung für Erprobungen von elektrischen und hybriden Antriebssträngen
(2019)
Application of a robotic THz imaging system for sub-surface analysis of ancient human remains
(2019)
We used a robotic-based THz imaging system to investigate the sub-surface structure of an artificially mummified ancient Egyptian human left hand. The results obtained are compared to the results of a conventional CT and a micro-CT scan. Using such a robotic THz system promises new insights into the sub-surface structure of human remains. The depth resolution of the THz images exceeds the resolution of a conventional CT scan and is comparable with a micro-CT scan. The advantage of THz measurements over micro-CT scans is the fact that even comparatively large samples, like complete bodies, can be scanned. These would not fit into a conventional micro-CT scanner.
Integrated laser based pre‐tempering at laser welding of AISI 1045 steel by using 3D‐scanner optics
(2021)
Fluorescence Microscopy-Based Quantitation of GLUT4 Translocation: High Throughput or High Content?
(2020)
Preliminary study: Polishing force measurement by viscosity - the return of ketchup polishing
(2021)
Pharmaceutical agents or drugs often have a pronounced impact on protein-protein interactions in cells, and in particular, cell membranes. Changes of molecular conformations as well as of intermolecular interactions may affect dipole-dipole interaction between chromophoric groups, which can be proven by measuring the Förster resonance energy transfer (FRET). If these chromophores are located within or in close proximity to the plasma membrane, they are excited preferentially by an evanescent electromagnetic wave upon total internal reflection (TIR) of an incident laser beam. For the TIR-FRET screening of larger cell collectives, we performed three separate steps: (1) setting up of a membrane associated test system for probing the interaction between the epidermal growth factor receptor (EGFR) and the growth factor receptor-bound protein 2; (2) use of the Epac-SH188 sensor for quantitative evaluation under the microscope; and (3) application of a TIR fluorescence reader to probe the interaction of GFP with Nile Red. In the first two steps, we measured FRET from cyan (CFP) to yellow fluorescent protein (YFP) by spectral analysis and fluorescence lifetime imaging (FLIM) upon illumination of whole cells (epi-illumination) as well as selective illumination of their plasma membranes by TIR. In particular, TIR excitation permitted FRET measurements with high sensitivity and low background. The Epac sensor showed a more rapid response to pharmaceutical agents, e.g., Forskolin or the A2B adenosine receptor agonist NECA, in close proximity to the plasma membrane compared to the cytosol. Finally, FRET from a membrane associated GFP to Nile Red was used to test a multi-well TIR fluorescence reader with simultaneous detection of a larger number of samples.
Forming complex parts out of high and ultra-high strength aluminium alloys has proved to be more challenging in comparison to the currently used deep drawing steels. Nevertheless, aluminium alloys show a limited formability in contrast with, for example, deep drawing steels. Novel processes like Warm-forming, W-Temper or Hotforming, offer the potential to produce light and highly integrated one-piece components from such aluminium alloys at elevated temperatures. When considering aluminium alloys of the 7000 group, which can reach strength values (UTS) of about 600 MPa, crash components such as side impact bars would offer a suitable field of application.
Forming at elevated temperatures, in particular with the Hotforming process, offers high potential in the production of complex structural components on the one hand and in the use of existing press hardening equipment on the other. To date, the material behaviour of aluminium alloys in the 7000 group, applied in such processes and in the later final state after forming, is not sufficiently known.
Therefore, in this study, systematic investigations on the formability and the final strength during and after forming at elevated temperature of the EN AW-7075 aluminium wrought alloy from different suppliers are conducted. In general, material- and damage/ failure models were created and implemented into simulation in order to make predictions. Characterisation of the plastic material properties on the basis of various tensile specimens as shear-, notched-, tensile- and Erichsen tests are carried out to adapt the complex material- and failure models such as Barlat YLD2000 and GISSMO to the experimental values using a parameter optimisation. These were made for the material conditions during forming, i.e. after solution heat treatment, the final condition after artificial ageing at 180°C for 20 minutes, which corresponds to the cathodic dip coating, and the T6 condition, which is the highest strength condition.
To evaluate a suitable friction coefficient for high temperature forming processes, anti-friction agents are screened, and the potential applicability evaluated by strip-drawing tests. Thereby, using an analytical relationship, friction coefficients are determined at room temperature and 180°C, which are used as corresponding friction model for the finite element forming simulation.
Crash simulations using the nonlinear finite element method (FEM) of side impact protection beams are used to demonstrate the weight saving potential of high and ultra-high strength aluminium alloys compared to a beam made of press hardened steel. A weight saving of about 20 % could be achieved with the same crash performance. This can be significantly increased to around 30 % - 40 % by using local reinforcements such as CFRP or GFRP (carbon/ glass fibre reinforced plastic) patch. For this reason, a novel process was developed which is based on the conventional Hotforming process with an integrated thermal direct joining step called “Extended Hotforming”.
Subsequently, a heatable forming tool for the production of a serial like sheet metal side impact beam was developed to validate the finite element simulation and to demonstrate the potential of the forming processes at elevated temperatures for aluminium sheet metal components.
Lösungsansätze
(2021)
Direct digital manufacturing – the role of cost accounting for online hubs to access industry 4.0
(2021)