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Young but not Naive: Leaders of Tomorrow Expect Limits to Digital Freedom to Preserve Freedom
(2021)
Wie werden wir digital?
(2020)
WAR FOR TALENTS MEETS FACIAL EXPRESSION - leveraging recruiting videos in professional service firms
(2020)
The Dimensional Accuracy of Thin-Walled Parts Manufactured by Laser-Powder Bed Fusion Process
(2020)
Relevance and Adoption of AI technologies in German SMEs – Results from Survey-Based Research
(2021)
Potentials of Digital Business Models – Empirical investigation of data driven impacts in industry
(2018)
Potential Benefits of Enterprise Architecture Management in the Digital Transformation Process
(2020)
Organische Chemie
(2021)
On the road again: Wie kann die Arbeitsgestaltung zur Arbeitsfreude bei mobiler Arbeit beitragen?
(2020)
The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, here we successfully target the monomeric structural ensemble of αSyn and thereby identify novel drug-like small molecules that impact multiple pathogenic processes. Using a surface plasmon resonance high-throughput screen, in which monomeric αSyn is incubated with microchips arrayed with tethered compounds, we identified novel αSyn interacting drug-like compounds. Because these small molecules could impact a variety of αSyn forms present in the ensemble, we tested representative hits for impact on multiple αSyn malfunctions in vitro and in cells including aggregation and perturbation of vesicular dynamics. We thereby identified a compound that inhibits αSyn misfolding and is neuroprotective, multiple compounds that restore phagocytosis impaired by αSyn overexpression, and a compound blocking cellular transmission of αSyn. Our studies demonstrate that drug-like small molecules that interact with native αSyn can impact a variety of its pathological processes. Thus, targeting the intrinsically disordered ensemble of αSyn offers a unique approach to the development of small molecule research tools and therapeutics for Parkinson's disease.
Lower bounds on the sum of 25th-powers of univariates lead to complete derandomization of PIT
(2020)
Integrated laser based pre‐tempering at laser welding of AISI 1045 steel by using 3D‐scanner optics
(2021)
Highlighting Thermal Post-Treatment for Improving Long-Term Media-Tightness of Polymer-Metal Hybrids
(2021)
Hardcore Gamer Profiling
(2018)
Fluorescence Microscopy-Based Quantitation of GLUT4 Translocation: High Throughput or High Content?
(2020)
Direct digital manufacturing – the role of cost accounting for online hubs to access industry 4.0
(2021)
Development and trial of a blended learning concept for students in engineering study courses
(2018)