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Cyber security in family businesses - empirical assessments from the perspective of German SMEs
(2020)
Organizational Aspects of Cyber Security in Family Firms – an Empirical Study of German Companies
(2021)
Adoption of artificial intelligence technologies in German SMEs — Results from an empirical study
(2021)
One Single Click is enough – an Empirical Study on Human Threats in Family Firm Cyber Security
(2021)
Relevance and Adoption of AI technologies in German SMEs – Results from Survey-Based Research
(2021)
The effect of personality and gender on individuals' propensity for corruption and corrupt behavior
(2020)
The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, here we successfully target the monomeric structural ensemble of αSyn and thereby identify novel drug-like small molecules that impact multiple pathogenic processes. Using a surface plasmon resonance high-throughput screen, in which monomeric αSyn is incubated with microchips arrayed with tethered compounds, we identified novel αSyn interacting drug-like compounds. Because these small molecules could impact a variety of αSyn forms present in the ensemble, we tested representative hits for impact on multiple αSyn malfunctions in vitro and in cells including aggregation and perturbation of vesicular dynamics. We thereby identified a compound that inhibits αSyn misfolding and is neuroprotective, multiple compounds that restore phagocytosis impaired by αSyn overexpression, and a compound blocking cellular transmission of αSyn. Our studies demonstrate that drug-like small molecules that interact with native αSyn can impact a variety of its pathological processes. Thus, targeting the intrinsically disordered ensemble of αSyn offers a unique approach to the development of small molecule research tools and therapeutics for Parkinson's disease.
The Dimensional Accuracy of Thin-Walled Parts Manufactured by Laser-Powder Bed Fusion Process
(2020)
Designing a Randomized Trial with an Age Simulation Suit-Representing People with Health Impairments
(2020)
Application of a robotic THz imaging system for sub-surface analysis of ancient human remains
(2019)
We used a robotic-based THz imaging system to investigate the sub-surface structure of an artificially mummified ancient Egyptian human left hand. The results obtained are compared to the results of a conventional CT and a micro-CT scan. Using such a robotic THz system promises new insights into the sub-surface structure of human remains. The depth resolution of the THz images exceeds the resolution of a conventional CT scan and is comparable with a micro-CT scan. The advantage of THz measurements over micro-CT scans is the fact that even comparatively large samples, like complete bodies, can be scanned. These would not fit into a conventional micro-CT scanner.
Integrated laser based pre‐tempering at laser welding of AISI 1045 steel by using 3D‐scanner optics
(2021)