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While Virtual Reality (VR) has been applied to various domains to provide new visualization and interaction capabilities, enabling programmers to utilize VR for their software development and maintenance tasks has been insufficiently explored. In this paper, we present the Hyper-Display Environment (HyDE) in the form of a mixed-reality (HyDE-MR) or virtual reality (HyDE-VR) variant respectively, which provides simultaneous multiple operating system window visualization with integrated keyboard/mouse viewing and interaction using MR or in pure VR via a virtual keyboard. This paper applies HyDE in a software development case study as an alternative to typical non-VR Integrated Development Environments (IDEs), supporting software engineering tasks with multiple live screens in VR as an augmented virtuality. The MR solution concept enables programmers to benefit from VR visualization and virtually unlimited information displays while supporting their more natural keyboard interaction for basic code-centric tasks. Thus, developers can leverage VR paradigms and capabilities while directly interacting with their favorite tools to develop and maintain program code. A prototype implementation is described, with a case study demonstrating its feasibility and an initial empirical study showing its potential.
Hardcore Gamer Profiling
(2018)
Potentials of Digital Business Models – Empirical investigation of data driven impacts in industry
(2018)
Development and trial of a blended learning concept for students in engineering study courses
(2018)
Enterprise Architecture (EA) Frameworks (EAFs) have attempted to support comprehensive and cohesive modeling and documentation of the enterprise. However, these EAFs were not conceived for today’s rapidly digitalized enterprises and the associated IT complexity. A digitally-centric EAF is needed, freed from the past restrictive EAF paradigms and embracing the new potential in a data-centric world. This paper proposes an alternative EAF that is digital, holistic, and digitally sustainable - the Digital Diamond Framework. D2F is designed for responsive and agile enterprises, for aligning business plans and initiatives with the actual enterprise state, and addressing the needs of EA for digitized structure, order, modeling, and documentation. The feasibility of D2F is demonstrated with a prototype implementation of an EA tool that applies its principles, showing how the framework can be practically realized, while a case study based on ArchiSurance example and an initial performance and scalability characterization provide additional insights as to its viability.
Databases are becoming an ubiquitous and integral part of most software as the data era and the Internet of Everything unfolds. Alternative database types such as NoSQL grow in popularity and allow data to be stored and accessed more simply or in new ways. Thus, software developers, not just database specialists, are more likely to encounter and need to deal with databases. Virtual Reality (VR) technology has grown in popularity, yet its integration in the software development tool chain has been limited. One potential application area for VR technology that has not been sufficiently explored is database-model visualization. This paper describes Virtual Reality Immersion in Data Models (VRiDaM), a generic database-model approach for visualizing, navigating, and conveying database-model information interactively. It describes and explores both native VR and WebVR solution concepts, with prototypes showing the viability of the approach.
Application of a robotic THz imaging system for sub-surface analysis of ancient human remains
(2019)
We used a robotic-based THz imaging system to investigate the sub-surface structure of an artificially mummified ancient Egyptian human left hand. The results obtained are compared to the results of a conventional CT and a micro-CT scan. Using such a robotic THz system promises new insights into the sub-surface structure of human remains. The depth resolution of the THz images exceeds the resolution of a conventional CT scan and is comparable with a micro-CT scan. The advantage of THz measurements over micro-CT scans is the fact that even comparatively large samples, like complete bodies, can be scanned. These would not fit into a conventional micro-CT scanner.
Pharmaceutical agents or drugs often have a pronounced impact on protein-protein interactions in cells, and in particular, cell membranes. Changes of molecular conformations as well as of intermolecular interactions may affect dipole-dipole interaction between chromophoric groups, which can be proven by measuring the Förster resonance energy transfer (FRET). If these chromophores are located within or in close proximity to the plasma membrane, they are excited preferentially by an evanescent electromagnetic wave upon total internal reflection (TIR) of an incident laser beam. For the TIR-FRET screening of larger cell collectives, we performed three separate steps: (1) setting up of a membrane associated test system for probing the interaction between the epidermal growth factor receptor (EGFR) and the growth factor receptor-bound protein 2; (2) use of the Epac-SH188 sensor for quantitative evaluation under the microscope; and (3) application of a TIR fluorescence reader to probe the interaction of GFP with Nile Red. In the first two steps, we measured FRET from cyan (CFP) to yellow fluorescent protein (YFP) by spectral analysis and fluorescence lifetime imaging (FLIM) upon illumination of whole cells (epi-illumination) as well as selective illumination of their plasma membranes by TIR. In particular, TIR excitation permitted FRET measurements with high sensitivity and low background. The Epac sensor showed a more rapid response to pharmaceutical agents, e.g., Forskolin or the A2B adenosine receptor agonist NECA, in close proximity to the plasma membrane compared to the cytosol. Finally, FRET from a membrane associated GFP to Nile Red was used to test a multi-well TIR fluorescence reader with simultaneous detection of a larger number of samples.
The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, here we successfully target the monomeric structural ensemble of αSyn and thereby identify novel drug-like small molecules that impact multiple pathogenic processes. Using a surface plasmon resonance high-throughput screen, in which monomeric αSyn is incubated with microchips arrayed with tethered compounds, we identified novel αSyn interacting drug-like compounds. Because these small molecules could impact a variety of αSyn forms present in the ensemble, we tested representative hits for impact on multiple αSyn malfunctions in vitro and in cells including aggregation and perturbation of vesicular dynamics. We thereby identified a compound that inhibits αSyn misfolding and is neuroprotective, multiple compounds that restore phagocytosis impaired by αSyn overexpression, and a compound blocking cellular transmission of αSyn. Our studies demonstrate that drug-like small molecules that interact with native αSyn can impact a variety of its pathological processes. Thus, targeting the intrinsically disordered ensemble of αSyn offers a unique approach to the development of small molecule research tools and therapeutics for Parkinson's disease.
Adding evidence of the effects of treatments into relevant Wikipedia pages: a randomised trial
(2020)
Lower bounds on the sum of 25th-powers of univariates lead to complete derandomization of PIT
(2020)
Wie werden wir digital?
(2020)
Potential Benefits of Enterprise Architecture Management in the Digital Transformation Process
(2020)