Optik und Mechatronik
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Purpose: The purpose of this thesis is to provide a comprehensive literature review about albinism as an inherited metabolic disorder of melanin synthesis along with those related conditions impacting the visual system. As such, it addresses eye care emphasizing the visual consequences of albinism along with diagnostic and treatment options.
Methods: Background knowledge about ocular development is given as well as information about etiological biochemical and genetic processes. The current classification, clinical findings and their assessment and management options are presented based on recent results of research. In conclusion, two case reports are described as examples of visual care options.
Results: Melanin plays a big role in the retinal and chiasmal development. Melanin biosynthesis can be disrupted by different genes in various ways which leads to the current classification of albinism. Clinical findings include fundus hypopigmenta-tion, nystagmus, iris transillumination, photophobia, foveal hypoplasia, excessive chiasmal decussation, reduced visual acuity, high astigmatism (with-the-rule), strabismus and decreased stereopsis. Treatment options to improve visual acuity, fixation and binocularity are (tinted) prescription lenses and contact lenses, low vision aids, surgical procedures and vision therapy. Medication and supplementa-tion for increased pigmentation are currently being tested on mice.
Conclusions: Albinism is caused by genetic mutations resulting in ocular and cutaneous hypopigmentation. It establishes various phenotypes that require different therapy approaches in order to improve vision and therefore quality of life.
Purpose: Usually, a theory of attention upon gazed-at locations is applied. More parameters than gaze location can be derived to improve the theory of attention allocation. The aim of this study was to identify parameters related to eye tracking, that are suitable indicators of attention.
Methods: Binocular eye tracking data was collected with the Eye Tribe tracking system (The Eye Tribe Aps, Copenhagen, Denmark) for the task of visual exploration of the painting “Unexpected Visitors” by Ilya Repin. 20 subjects (valid data: 19/20) had to look at this painting for about two and a half minutes in order to generate fatigue and inattention. In a second step, suitable parameters of attention were transferred to a data set (8 subjects, valid data: 6/8) on a perimetric task executed with the OCTOPUS 900 perimeter (Haag-Streit, Köniz, Switzerland). Monocular parameters could be applied on the perimetric task, the error rate (false positive and false negative catch trials, 5 % each) were taken as additional parameter.
Results: For the image viewing task, the only parameter showing significance was the average level (a10) of fatigue waves (p = 0.00024, ANOVA, ∆ = -0.8316 px). Blink duration (∆ =-270.4 ms), pupil variability (∆ = -0.17868), saccade length (∆ =-0.3135 px) and fixation duration (∆ = 186.5 ms) did not change significantly, but showed relevant trends by differences ∆ of their median between the first and last tenth of the recording time. Blink rate and the Index of Cognitive Activity (ICA) did neither show significant changes nor relevant trends. Vergence accuracy failed to indicate fatigue due to variability between subjects and comparatively small effect size. For the perimetric data, in 3 of 6 subjects fatigue waves over a limited time window could be observed. Only for one subject, a relevant increase in false negative responses to catch trials (50 percentage points) could be observed.
Conclusion: Pupil diameter variability, saccade length, fixation duration and fatigue waves were the parameters indicating fatigue. Only the latter parameter has the potential to be applied to perimetric data.
Purpose
Automated scanpath comparison metrics should deliver an objective method to
evaluate the similarity of scanpaths. The aim of this thesis is an evaluation of
seven existing scanpath comparison metrics in static and dynamic tasks in order
to provide a guidline that helps to decide which algorithm has to be chosen for a
special kind of task.
Methods
The applicability of the algorithms for a static, visual search task and a dynamic,
interactive video game task as well as their constraints and limitations were tested.
Therefore, binocular gaze data were recorded by using the eye tracking system The
Eye Tribe (The Eye Tribe ApS, Copenhagen/ Denmark). Objective task performance
measures from 21 subjects were used in order to create scanpath groupings
for which a relevant effect of dissimilarity was to be expected. Objective task performance
measures such as task performance time were statistically evaluated and
compared to the results gained by the comparison metrics.
Results
Four of the algorithms being used successfully identified differences for static and
dynamic tasks: MultiMatch, iComp, SubsMatch and the Hidden Markov Model.
ScanMatch was very sensitive for the static task but not applicable to the dynamic
task whereas FuncSim was suitable for dynamic but not for static tasks. Eyenalysis
failed to detect any effect.
Conclusion
The applicability of scanpath comparison metrics depends on the state of the task,
respectively on the kind of experimental set up. In future, the application area for
eye tracking will expand and an improvement of automated scanpath comparison
metrics is therefore required.