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Identification and quantitative segmentation of individual blood vessels in mice visualized with preclinical imaging techniques is a tedious, manual or semiautomated task that can require weeks of reviewing hundreds of levels of individual data sets. Preclinical imaging, such as micro-magnetic resonance imaging (μMRI) can produce tomographic datasets of murine vasculature across length scales and organs, which is of outmost importance to study tumor progression, angiogenesis, or vascular risk factors for diseases such as Alzheimer’s. Training a neural network capable of accurate segmentation results requires a sufficiently large amount of labelled data, which takes a long time to compile. Recently, several reasonably automated approaches have emerged in the preclinical context but still require significant manual input and are less accurate than the deep learning approach presented in this paper—quantified by the Dice score. In this work, the implementation of a shallow, three-dimensional U-Net architecture for the segmentation of vessels in murine brains is presented, which is (1) open-source, (2) can be achieved with a small dataset (in this work only 8 μMRI imaging stacks of mouse brains were available), and (3) requires only a small subset of labelled training data. The presented model is evaluated together with two post-processing methodologies using a cross-validation, which results in an average Dice score of 61.34% in its best setup. The results show, that the methodology is able to detect blood vessels faster and more reliably compared to state-of-the-art vesselness filters with an average Dice score of 43.88% for the used dataset.
EMDR-Therapie im Vergleich zu EMDR-Therapie, erweitert durch taktilen und auditorischen Stimulus
(2023)
EMDR (Eye Movement Desensitization and Reprocessing) ist ein neurobiologisch orientierter psychotherapeutischer Ansatz zu Behandlung von posttraumatischen Belastungsstörungen (PTBS) und anderen belastenden Lebensereignissen. Dabei werden Augenbewegungen eingesetzt, um die Verarbeitung und Integration traumatischer Erinnerungen zu erleichtern. Diese nichtinterventionelle Anwendungsbeobachtung untersucht die Bedeutung von Augenbewegungen in EMDR und potenzielle Vorteile der Einbeziehung auditiver und taktiler Reize in die Therapie.
Feedback management in hearing aids and its challenges have been there for over 60 years. The basic principles of feedback management are still in use to prevent the hearing aids from oscillation. This work focusses on the feedback management in custom style hearing aids by comparing four different Invisible-In-the-Canal (IIC) hearing aids. Four test set-ups were created to find valid and reli-able methods and set-ups to test custom hearing aids for their feedback management. The goal was to find out if they could provide 1) stable gain, 2) good sound quality, 3) indicate specific frequencies audible feedback occurs and 4) to test the clinical robustness through subjective experience rating. The principle was: matched gain – matched acoustics.
Technikethik im Jahr 2021
(2021)