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Abstract
1.1 Purpose
The purpose of this study is to prescribe follicular-like conjunctivitis associated with Siliconhydrogels
(FoCoSi) in silicone hydrogel contact lens wearers as a novel subtype of
the well prescribed contact lens induced papillary conjunctivitis (CLPC).
1.2 Methods
1211 patients who wore silicon hydrogels were included in this prospective, nonrandomised,
single center study. Subjective symptoms and clinical signs were evaluated
for daily wear (DW) and continuous wear (CW) populations for several (Lotrafilcon A,
Lotrafilcon B, Senofilcon A, Galyfilcon A) silicon hydrogel lens types. CCLRU and other
specifically developed grading scale were utilized for evaluation. Grading of 2 and above
was rated as clinically significant. Statistical evaluation was performed for eyes rather
than subjects.
1.3 Results
The clinical presentation of FoCoSi could be confirmed and showed an incidence of
3.8%. Lotrafilcon A followed by Senofilcon A on a CW modality presented, with a risk
ratio of 2.49 and 1.53 respectively, the highest affinity for developing FoCoSi. Fluorescein
positive spots showed the closest correlation with subjective symptoms reported
by patients and divided FoCoSi into an active and dormant form. Besides Protein, Lipid
deposition on the contact lens surface and air pollution like Ozone or fine and ultrafine
particles seems to be important factors in developing FoCoSi, whereas mechanical irritation
played a minor role.
1.4 Conclusion
FoCoSi is a novel and relevant subtype of CLPC. Further studies should be performed
to validate these findings and clear up several questions about the aetiology of FoCoSi
and CLPC.
Keywords: Giant papillary conjunctivitis (GPC), contact lens-induced papillary conjunctivitis
(CLPC), follicular-like conjunctivitis associated with siliconhydrogels (FoCoSi)
The present thesis deals with alternative powertrains, focusing on electric vehicles
and hybrid vehicles and which of those alternative powertrains is considered as
sustainable for the future. It explores the question, which alternative powertrain is
worthwhile investing in for German automotive suppliers. The aim is to clarify
which of the two powertrains is already established on the market and what the
future prospects of those powertrains are. The question here is evaluated based on
the analysis of current literature as well as through the use of a SWOT analysis
and the use of the scoring model.
As a result it is clear that there is a need for alternative powertrains and the entire
automotive industry invests a lot in the development and research of alternative
powertrains. According to the German Federal Government, one million electric
vehicles should be on German roads by 2020. With pure electric vehicles, however,
the goal will be difficult to reach. Therefore, there is a lot of vested interest in
the development of hybrid vehicles on the market. It shows that the hybrid vehicle
has considerable advantages over the electric vehicle and the hybrid vehicle is
already seen as a transitional solution for pure electric vehicles. The hybrid vehicle
is also already established in the market and has better chances on the market
in the future. Therefore, it makes sense for German automotive suppliers to invest
in hybrid vehicles and to focus on this market, since there the chances of success
are greater and the future potential of this market is higher.
Purpose
The purpose of this study was to investigate the correlation of measured visual acuity
(VA) both static and dynamic obtained with static and dynamic measuring tests, as well
as, response time to visual stimulus and analysis of its influence on dynamic visual
acuity. The aim was to compare the results gathered for the three age groups and
analyze the possible differences.
Methods
The test groups consisted of 75 subjects between 10 and 60 years old, categorized in
three age groups. The measurements of static and dynamic visual acuity and reaction
time were conducted. The set of nine tests (five with radial magnification speed and four
simulating driving condition at 72 km/h and 130 km/h) was designed in order to measure
dynamic visual acuity and the set of two tests for reaction time measurement.
Results
Compared to static visual acuity in both tests, the results obtained with measurements
of dynamic visual acuity resulted in lower values depending on Landolt ring size and
magnification speed of animation. In average, the dynamic visual acuities in tests with
different magnification speeds were lower than static by 0.4 visual acuity units, or 31%
and the average of dynamic visual acuity after subtracting motoric component (reaction
time) was for 0.2 visual acuity worse than static or 15%. In the second test simulating
driving conditions at 72 km/h the average drop in dynamic visual acuity was 33% while
at 130 km/h average drop for younger and middle age groups was 37% and for older
group was 44% and after subtracting motor component values for 72 km/h speed
simulation average drop in visual acuity values was 23% for all three groups; for 130
km/h speed simulation younger and middle aged group average drop of visual acuity
was 20% and with older group it was 24%.
Conclusion
The tests used in this study were simple and fast and revealed significant difference
between static and dynamic visual acuity and influence of reaction time on dynamic
Nataša Vujko Muždalo Abstract
2
visual acuity values. It is hoped that this thesis will be a positive contribution in testing
and training of dynamic visual and sensory response skill with drivers, sportsmen and
people with visual-motor dysfunction.
Keywords: Dynamic visual acuity (DVA), static visual acuity (SVA), reaction time (RT),
motoric component, dynamic visual acuity test, reaction time test, radial increase in size
The increasing prevalence of myopia throughout the industrialized world in recent decades has caused costs and problems for the eye health. Changed lifestyle and behavior are the main causes. For the pathogenesis of myopia, the amount of time spent outdoor and near activities play an important role. Various options for the treatment of myopia have been described as effective in the literature. Normal single vision glasses and contact lenses can only provide clear vision, but do not reduce myopia progression. Orthokeratology shows a slowing of axial growth, but has an increased risk of infectious keratitis. Low-dose atropine (0.01%) is currently the best pharmacological option. It proved safe, effective and showed the least rebound effect with negligible side effects. Other options for the treatment of myopia include special glasses, behavioral changes and prolonged outdoor exposure (to prevent the onset of myopia), as well as other methods. An increasingly important myopia management option is multifocal contact lenses, that provide a peripheral treatment zone producing myopic defocus. Such myopia control lenses are available as customized or as daily or monthly lenses. Children benefit from wearing contact lenses more than just having refractive error correction and myopia control, they have a better self-esteem and improved quality of life. The numerous findings on the safety and efficacy of soft multifocal distance center contact lenses in children to reduce the progression of myopia suggest that this modality should be considered as a main treatment option. Less, but similar to orthokeratology, when wearing soft lenses there is a risk of developing potentially serious complications such as microbial keratitis. The introduction of child-appropriate risk minimization strategies, and patient and parent education with regular monitoring is essential and leads to successful contact lens wear. This literature review summarized the actual knowledge about myopia management, prevalence, etiology and the visual and healthy consequences of myopia.
The three currently most important strategies for slowing the progression of myopia are soft multifocal distance center contact lenses, Orthokeratology and low-dose atropine ophthalmic drops.
This paper aims to provide essential information about the formal aspects of the adjustment process companies in Southern Germany utilize to adjust their employees to new surroundings. In particular, it shall be investigated and defined what formal aspects are and when firms apply them. Literature shows that companies do implement language courses, intercultural trainings or provide further information about the host country before a stay abroad. Nevertheless, the phases during and after the assignment are not taken into account with the required importance. Additionally, since national culture can be broken down into different layers, the organizational culture as one layer was analyzed, too.By conducting a quantitative research among companies in Baden-Württemberg, this paper shows the different approaches for dealing with a stay abroad. Scientific literature about the topic of adjustment of globally assigned workers shall help emphasizing the need of a deeper cultural insight. Furthermore, by attempting to explain the organizations’ culture, a better understanding of the chosen training methods shall be created. Definitions in the beginning helped to understand the concept of culture, the notion and the phases of adjustment. Almost all collected data has been accessed either through JSTOR (a digital library founded to help academic libraries or publishers) or similar databases, through the companies’ websites or through the survey results it selves.The results of this research show that the phase before the stay abroad is organized well. Companies offer pre-departure training, but during and after the expatriate time a lack of support is being observed. The firms obviously underestimate the necessary help needed during the assignment and in the return phase, which is why the thesis attempts to fill this gap. Through the organizational culture, described on the companies’ webpages the author was able to draw a conclusion to the applied training methods, which results in a consistent overall picture of the described firms. Companies from the automotive sector had the highest return rate in the survey, which is why particular attention was paid to it.
This research project is of particular importance since there is a lack of adequate data on pediatric eye and vision disorders in Russia, particularly in the Volga region. In the present study, we estimate the prevalence of vision disorders among school-aged children who participated in a vision screening program in Samara, Russia. The relationship between learning-related visual dysfunctions is explored in depth, such to illustrate the connection between vision and learning. Hence, a key feature in this study is the inclusion of binocular vision disorders among the conditions tested.
The present study deals with the topic how a town can use its cultural heritage or,
more precisely, its industrial culture as a means to market itself as an innovative
business location and to foster a more pronounced sense of civic cohesion among
residents. Economic theory suggests that, nowadays, traditional location factors
such as access to resources and a performant infrastructure are less important than
in the industrial age. Recently, factors like a city’s potential to generate and retain
human and creative capital have emerged. Accordingly, the economic and social
role of cities has shifted – from a place where workers lived and manufactured
goods towards a deeply interwoven ecosystem of knowledge-intense value creation.
The question at the root of the present study is how Heidenheim’s rich industrial
cultural heritage can be used as a future-pointing source of power for rebranding
the town. This rebranding concept has to be developed according to the town’s role
in past, present and future, thus creating actual economic and societal value.
Industrial culture bears branding potential and is closely related to various aspects
of modern life and work. The study examines possibilities to create awareness for
these relations connecting past, present and future. Their relevance shall be
emphasized in order to establish both points of orientation and authenticity of place
in times when macroeconomic and societal trends are difficult to predict. Ideally,
residents shall be given a sort of local identification to hold on to, and potential
investors and entrepreneurs shall be encouraged to sustainably experience the
innovation-based DNA of Heidenheim. Therefore, the study searches for a value
proposition that takes into account the points mentioned above on terms of an
innovative theoretic framework. As a result of this thesis, precise suggestions for
the implementation of a new branding strategy based on the conceptual guidelines
developed in this study will be proposed to the municipality of Heidenheim and, in
addition, an interface using principles of virtual and augmented reality will be
introduced.
Purpose
Automated scanpath comparison metrics should deliver an objective method to
evaluate the similarity of scanpaths. The aim of this thesis is an evaluation of
seven existing scanpath comparison metrics in static and dynamic tasks in order
to provide a guidline that helps to decide which algorithm has to be chosen for a
special kind of task.
Methods
The applicability of the algorithms for a static, visual search task and a dynamic,
interactive video game task as well as their constraints and limitations were tested.
Therefore, binocular gaze data were recorded by using the eye tracking system The
Eye Tribe (The Eye Tribe ApS, Copenhagen/ Denmark). Objective task performance
measures from 21 subjects were used in order to create scanpath groupings
for which a relevant effect of dissimilarity was to be expected. Objective task performance
measures such as task performance time were statistically evaluated and
compared to the results gained by the comparison metrics.
Results
Four of the algorithms being used successfully identified differences for static and
dynamic tasks: MultiMatch, iComp, SubsMatch and the Hidden Markov Model.
ScanMatch was very sensitive for the static task but not applicable to the dynamic
task whereas FuncSim was suitable for dynamic but not for static tasks. Eyenalysis
failed to detect any effect.
Conclusion
The applicability of scanpath comparison metrics depends on the state of the task,
respectively on the kind of experimental set up. In future, the application area for
eye tracking will expand and an improvement of automated scanpath comparison
metrics is therefore required.
Identification and quantitative segmentation of individual blood vessels in mice visualized with preclinical imaging techniques is a tedious, manual or semiautomated task that can require weeks of reviewing hundreds of levels of individual data sets. Preclinical imaging, such as micro-magnetic resonance imaging (μMRI) can produce tomographic datasets of murine vasculature across length scales and organs, which is of outmost importance to study tumor progression, angiogenesis, or vascular risk factors for diseases such as Alzheimer’s. Training a neural network capable of accurate segmentation results requires a sufficiently large amount of labelled data, which takes a long time to compile. Recently, several reasonably automated approaches have emerged in the preclinical context but still require significant manual input and are less accurate than the deep learning approach presented in this paper—quantified by the Dice score. In this work, the implementation of a shallow, three-dimensional U-Net architecture for the segmentation of vessels in murine brains is presented, which is (1) open-source, (2) can be achieved with a small dataset (in this work only 8 μMRI imaging stacks of mouse brains were available), and (3) requires only a small subset of labelled training data. The presented model is evaluated together with two post-processing methodologies using a cross-validation, which results in an average Dice score of 61.34% in its best setup. The results show, that the methodology is able to detect blood vessels faster and more reliably compared to state-of-the-art vesselness filters with an average Dice score of 43.88% for the used dataset.