Open Access
Refine
Year of publication
Document Type
- Article (141)
- Conference Proceeding (72)
- Bachelor Thesis (12)
- Master's Thesis (12)
- Report (7)
- Doctoral Thesis (3)
Language
- English (247) (remove)
Keywords
- virtual reality (9)
- Business Process Management Systems (4)
- Fuzzy Logic (4)
- visualization (4)
- Myopia (3)
- Assignment Automation (2)
- Augmented Reality (2)
- Business Process Modeling Notation (2)
- Git (2)
- Studie (2)
- Systems Modeling Language (SysML) (2)
- artificial neural networks (2)
- machine learning (2)
- software configuration management (2)
- software design pattern detection (2)
- software engineering (2)
- systems engineering (2)
- systems modeling (2)
- version control systems (2)
- Adjustment Process (1)
- Affliliate Marketing (1)
- Agency Theory (1)
- Artificial Intelligence (1)
- Big Data (1)
- Business Process Modelling (1)
- Choroidal thickness (1)
- City Development (1)
- Comparison metrics (1)
- Cross-Cultural Training (1)
- Cultural Heritage Marketing (1)
- Defocus (1)
- Diffusion (1)
- Digitization (1)
- Diversity Marketing (1)
- Edge Detection (1)
- Eye tracking (1)
- Fixation (1)
- Germany (1)
- Geschlechterrollen (1)
- Industrial Culture (1)
- Industrial Heritage (1)
- Kantendetektion (1)
- Kontaktlinse (1)
- Kontaktlinsen (1)
- Marketing (1)
- Messgerät, Brillengläser, Rotationszentrum, Auge (1)
- Multifocal contact lenses (1)
- Mustererkennung (1)
- Myopia Control (1)
- Myopie Kontrolle (1)
- National/Organizational Culture (1)
- Orthokeratologie (1)
- Orthokeratology (1)
- Re- source Assignment Automation (1)
- Resource Allocation Algorithms (1)
- Resource Assignment Automation (1)
- Rule Engines (1)
- Scanpath (1)
- Share Repurchase (1)
- Staff Assignment Algorithms (1)
- Strategic analysis (1)
- Strategische Analyse (1)
- Umweltanalyse (1)
- Undervaluation (1)
- Visual search (1)
- albinism (1)
- augmented virtuality (1)
- automotive supplier (1)
- business process management (1)
- business process mining (1)
- code coverage (1)
- contact lens-induced papillary conjuctivitis CLPC (1)
- customized (1)
- data pipelines (1)
- data stream processing (1)
- electric vehicle (1)
- environmental analysis (1)
- event stream processing (1)
- event-driven architecture (1)
- follicular-like conjunctivitis associated with siliconhydrogels FoCoSi (1)
- gender roles (1)
- genes (1)
- giant papillary conjuctivitis GPC (1)
- graph analysis (1)
- graph embeddings (1)
- hybrid vehicle (1)
- integrated development environments (1)
- low vision (1)
- measuring device, ophthalmic lenses, center of rotation, eye (1)
- melanin (1)
- mixed reality (1)
- myopia management (1)
- peripheral myopic defocus (1)
- powertrain (1)
- process analysis (1)
- process mining (1)
- repeatability (1)
- requirements traceability (1)
- rule-based expert system (1)
- soft multifocal contact lens (1)
- software requirements traceability (1)
- software test coverage (1)
- software test traceability (1)
- software testing (1)
- software verification and validation (1)
- specialty coffee (1)
- stereoacuity threshold (1)
- stereopsis (1)
- stereotest (1)
- two-rod test (1)
- vision therapy (1)
Institute
The effect of personality and gender on individuals' propensity for corruption and corrupt behavior
(2020)
The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, here we successfully target the monomeric structural ensemble of αSyn and thereby identify novel drug-like small molecules that impact multiple pathogenic processes. Using a surface plasmon resonance high-throughput screen, in which monomeric αSyn is incubated with microchips arrayed with tethered compounds, we identified novel αSyn interacting drug-like compounds. Because these small molecules could impact a variety of αSyn forms present in the ensemble, we tested representative hits for impact on multiple αSyn malfunctions in vitro and in cells including aggregation and perturbation of vesicular dynamics. We thereby identified a compound that inhibits αSyn misfolding and is neuroprotective, multiple compounds that restore phagocytosis impaired by αSyn overexpression, and a compound blocking cellular transmission of αSyn. Our studies demonstrate that drug-like small molecules that interact with native αSyn can impact a variety of its pathological processes. Thus, targeting the intrinsically disordered ensemble of αSyn offers a unique approach to the development of small molecule research tools and therapeutics for Parkinson's disease.