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Institute
Enterprise Architecture (EA) Frameworks (EAFs) have attempted to support comprehensive and cohesive modeling and documentation of the enterprise. However, these EAFs were not conceived for today’s rapidly digitalized enterprises and the associated IT complexity. A digitally-centric EAF is needed, freed from the past restrictive EAF paradigms and embracing the new potential in a data-centric world. This paper proposes an alternative EAF that is digital, holistic, and digitally sustainable - the Digital Diamond Framework. D2F is designed for responsive and agile enterprises, for aligning business plans and initiatives with the actual enterprise state, and addressing the needs of EA for digitized structure, order, modeling, and documentation. The feasibility of D2F is demonstrated with a prototype implementation of an EA tool that applies its principles, showing how the framework can be practically realized, while a case study based on ArchiSurance example and an initial performance and scalability characterization provide additional insights as to its viability.
Relevance and Adoption of AI technologies in German SMEs – Results from Survey-Based Research
(2021)
This research project is of particular importance since there is a lack of adequate data on pediatric eye and vision disorders in Russia, particularly in the Volga region. In the present study, we estimate the prevalence of vision disorders among school-aged children who participated in a vision screening program in Samara, Russia. The relationship between learning-related visual dysfunctions is explored in depth, such to illustrate the connection between vision and learning. Hence, a key feature in this study is the inclusion of binocular vision disorders among the conditions tested.
Preliminary study: Polishing force measurement by viscosity - the return of ketchup polishing
(2021)
Potentials of Digital Business Models – Empirical investigation of data driven impacts in industry
(2018)
Potential Benefits of Enterprise Architecture Management in the Digital Transformation Process
(2020)
Organizational Aspects of Cyber Security in Family Firms – an Empirical Study of German Companies
(2021)
One Single Click is enough – an Empirical Study on Human Threats in Family Firm Cyber Security
(2021)
The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, here we successfully target the monomeric structural ensemble of αSyn and thereby identify novel drug-like small molecules that impact multiple pathogenic processes. Using a surface plasmon resonance high-throughput screen, in which monomeric αSyn is incubated with microchips arrayed with tethered compounds, we identified novel αSyn interacting drug-like compounds. Because these small molecules could impact a variety of αSyn forms present in the ensemble, we tested representative hits for impact on multiple αSyn malfunctions in vitro and in cells including aggregation and perturbation of vesicular dynamics. We thereby identified a compound that inhibits αSyn misfolding and is neuroprotective, multiple compounds that restore phagocytosis impaired by αSyn overexpression, and a compound blocking cellular transmission of αSyn. Our studies demonstrate that drug-like small molecules that interact with native αSyn can impact a variety of its pathological processes. Thus, targeting the intrinsically disordered ensemble of αSyn offers a unique approach to the development of small molecule research tools and therapeutics for Parkinson's disease.
Purpose
The purpose of this study was to investigate the correlation of measured visual acuity
(VA) both static and dynamic obtained with static and dynamic measuring tests, as well
as, response time to visual stimulus and analysis of its influence on dynamic visual
acuity. The aim was to compare the results gathered for the three age groups and
analyze the possible differences.
Methods
The test groups consisted of 75 subjects between 10 and 60 years old, categorized in
three age groups. The measurements of static and dynamic visual acuity and reaction
time were conducted. The set of nine tests (five with radial magnification speed and four
simulating driving condition at 72 km/h and 130 km/h) was designed in order to measure
dynamic visual acuity and the set of two tests for reaction time measurement.
Results
Compared to static visual acuity in both tests, the results obtained with measurements
of dynamic visual acuity resulted in lower values depending on Landolt ring size and
magnification speed of animation. In average, the dynamic visual acuities in tests with
different magnification speeds were lower than static by 0.4 visual acuity units, or 31%
and the average of dynamic visual acuity after subtracting motoric component (reaction
time) was for 0.2 visual acuity worse than static or 15%. In the second test simulating
driving conditions at 72 km/h the average drop in dynamic visual acuity was 33% while
at 130 km/h average drop for younger and middle age groups was 37% and for older
group was 44% and after subtracting motor component values for 72 km/h speed
simulation average drop in visual acuity values was 23% for all three groups; for 130
km/h speed simulation younger and middle aged group average drop of visual acuity
was 20% and with older group it was 24%.
Conclusion
The tests used in this study were simple and fast and revealed significant difference
between static and dynamic visual acuity and influence of reaction time on dynamic
Nataša Vujko Muždalo Abstract
2
visual acuity values. It is hoped that this thesis will be a positive contribution in testing
and training of dynamic visual and sensory response skill with drivers, sportsmen and
people with visual-motor dysfunction.
Keywords: Dynamic visual acuity (DVA), static visual acuity (SVA), reaction time (RT),
motoric component, dynamic visual acuity test, reaction time test, radial increase in size
Future lunar exploration will be based on in-situ resource utilization (ISRU) techniques. The most abundant raw material on the Moon is lunar regolith, which, however, is very scarce on Earth, making the study of simulants a necessity. The objective of this study is to characterize and investigate the sintering behavior of EAC-1A lunar regolith simulant. The characterization of the simulant included the determination of the phase assemblage, characteristic temperatures determination and water content analysis. The results are discussed in the context of sintering experiments of EAC-1A simulant, which showed that the material can be sintered to a relative density close to 90%, but only within a very narrow range of temperatures (20–30 °C). Sintering experiments were performed for sieved and unsieved, as well as for dried and non-dried specimens of EAC-1A. In addition, an analysis of the densification and mechanical properties of the sintered specimens was done. The sintering experiments at different temperatures showed that the finest fraction of sieved simulant can reach a higher maximum sintering temperature, and consequently a higher densification and biaxial strength. The non-dried powder exhibited higher densification and biaxial strength after sintering compared to the dried specimen. This difference was explained with a higher green density of the non-dried powder during pressing, rather than due to an actual influence on the sintering mechanism. Nevertheless, drying the powder prior to sintering is important to avoid the overestimation of the strength of specimens to be fabricated on the Moon.
Lower bounds on the sum of 25th-powers of univariates lead to complete derandomization of PIT
(2020)
Novel myopia control spectacle lenses induce peripheral contrast reduction via optical diffusion. It is suggested, that the contrast reduction alters retinal processes in the low-level neural circuity, leading to an inhibition of eye growth. The purpose of this thesis is to evaluate the influence of full-field contrast reduction on low-level neural processing of the retina, described by the edge contrast sensitivity.
Leveraging Augmented Reality to Support Context-Aware Tasks in Alignment with Business Processes
(2021)
The seamless inclusion of Augmented Reality (AR) with Business Process Management Systems (BPMSs) for Smart Factory and Industry 4.0 processes remains a challenge. Towards this end, this paper contributes an approach integrating context-aware AR into intelligent business processes to support and guide manufacturing personnel tasks and enable live task assignment optimization and support task execution quality. Our realization extends two BPMSs (Camunda and AristaFlow) and various AR devices. Various AR capabilities are demonstrated via a simulated industrial case study.
Learning for E-Learning
(2020)