Optik und Mechatronik
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- Optik und Mechatronik (106)
Wideband-tympanometry (WBT) could give more informative data about the tympanic condition than the conventional tympanometry. In the actual literature, the clinical profit of wideband-tympanometry in pediatric audiological settings is not well evaluated. The aim of this study was to analyze the additional clinical benefit.
Pharmaceutical agents or drugs often have a pronounced impact on protein-protein interactions in cells, and in particular, cell membranes. Changes of molecular conformations as well as of intermolecular interactions may affect dipole-dipole interaction between chromophoric groups, which can be proven by measuring the Förster resonance energy transfer (FRET). If these chromophores are located within or in close proximity to the plasma membrane, they are excited preferentially by an evanescent electromagnetic wave upon total internal reflection (TIR) of an incident laser beam. For the TIR-FRET screening of larger cell collectives, we performed three separate steps: (1) setting up of a membrane associated test system for probing the interaction between the epidermal growth factor receptor (EGFR) and the growth factor receptor-bound protein 2; (2) use of the Epac-SH188 sensor for quantitative evaluation under the microscope; and (3) application of a TIR fluorescence reader to probe the interaction of GFP with Nile Red. In the first two steps, we measured FRET from cyan (CFP) to yellow fluorescent protein (YFP) by spectral analysis and fluorescence lifetime imaging (FLIM) upon illumination of whole cells (epi-illumination) as well as selective illumination of their plasma membranes by TIR. In particular, TIR excitation permitted FRET measurements with high sensitivity and low background. The Epac sensor showed a more rapid response to pharmaceutical agents, e.g., Forskolin or the A2B adenosine receptor agonist NECA, in close proximity to the plasma membrane compared to the cytosol. Finally, FRET from a membrane associated GFP to Nile Red was used to test a multi-well TIR fluorescence reader with simultaneous detection of a larger number of samples.
Design Intelligence - Pitfalls and Challenges When Designing AI Algorithms in B2B Factory Automation
(2020)
Purpose
To determine the stereo threshold and inherent variability with a monitor-based two-rod test at various eccentricities of the visual field. Additionally, to evaluate the duration of this procedure.
Subjects and methods
A pilot trial was conducted in five ophthalmologically normal subjects (2 male and 3 female) aged 21 – 23 years. Two black rods on white background, which appeared under an angle of 1° were presented in a viewing distance of 5.0 meters. The right rod was stationary, whilst the left rod appeared under a stereoscopic parallax, with an either proximal or distal displacement to the image plane. Threshold determination was assessed at seven eccentricities of the visual field by a staircase method. Eccentricities were 0° centrally, 5° to the right and left, 10° to the right and left and 15° to the right and left of the visual field. Proximal and distal displacement as well as the sequence of eccentricities were presented in random order. Stereo acuity was measured in two different sessions for four subjects and in five different sessions for one subject. For all sessions the duration was recorded. All sessions were separated by a time interval of at least 24 hours and no longer than 7 days. Evaluation was made by Wilcoxon test and Kruskal Wallis test at the 95% confidence level (CI) and the median was assessed for all thresholds.
Results
Stereo acuity declines with increasing eccentricities of the retina similar to visual acuity. While at 0° eccentricity thresholds were found to be lowest with (median) 5.0 seconds of arc (‘’) and the CI (0.5’’, 30.5’’) for all measurements, they increased to 112.2’’ at 15° eccentricity to the left in proximal displacement. Distal it was 19.9’’ centrally and 112.2’’ to the right at 15° eccentricity with CI (0.5’’, 30.5’’) for all measurements.
Repeatability of the threshold determination was found to be best at 0° eccentricity with proximal displacement showing the exact same result in the repetitive session and poorest repetition was found at 15° eccentricity to the left with distal displacement. Distal repeatability was worse than proximal. Median and CI of duration time was 5.3 (3.2, 8.3) minutes.
Conclusion
Stereo acuity thresholds are repeatable however increase with increasing eccentricity. Repetitions of the threshold determination do not vary considerably. The duration of these measurements indicates the monitor-based two-rod test as a fast procedure, that can be applied in future studies. The test program is limited by an imperfect algorithm and the stereoscopic images evoke cues, this should be reworked.
The use of computers spread among the population, both for work and leisure purposes. This poses an increased risk factor for dry eye disease, a multifactorial disease influencing the surface of the eye. With the recent increasing usage of head-mounted displays, it is critical to determine whether or not they have the same impact on the tear film as conventional screens.
Purpose
Automated scanpath comparison metrics should deliver an objective method to
evaluate the similarity of scanpaths. The aim of this thesis is an evaluation of
seven existing scanpath comparison metrics in static and dynamic tasks in order
to provide a guidline that helps to decide which algorithm has to be chosen for a
special kind of task.
Methods
The applicability of the algorithms for a static, visual search task and a dynamic,
interactive video game task as well as their constraints and limitations were tested.
Therefore, binocular gaze data were recorded by using the eye tracking system The
Eye Tribe (The Eye Tribe ApS, Copenhagen/ Denmark). Objective task performance
measures from 21 subjects were used in order to create scanpath groupings
for which a relevant effect of dissimilarity was to be expected. Objective task performance
measures such as task performance time were statistically evaluated and
compared to the results gained by the comparison metrics.
Results
Four of the algorithms being used successfully identified differences for static and
dynamic tasks: MultiMatch, iComp, SubsMatch and the Hidden Markov Model.
ScanMatch was very sensitive for the static task but not applicable to the dynamic
task whereas FuncSim was suitable for dynamic but not for static tasks. Eyenalysis
failed to detect any effect.
Conclusion
The applicability of scanpath comparison metrics depends on the state of the task,
respectively on the kind of experimental set up. In future, the application area for
eye tracking will expand and an improvement of automated scanpath comparison
metrics is therefore required.