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Institute
Purpose: Although the frequency in which practitioners are fitting scleral
contact lenses is increasing, the recommendation for proper tear layer depth
(thickness) varies amongst experts. The main goal of this paper is to clinically
verify the effect of varying tear layer depths on induced corneal edema during
lens wear.
Methods: Ten subjects with healthy eyes were fitted with scleral lenses on their
right eye. Each of them was fit with two different lenses: one with an apical
clearance of 200 μm and another with an apical clearance of 600 μm. They wore
the lenses for 8 hours on two different days, with at least a one week wash-out
period. Lenses were applied at 8 a.m. on each of the testing days. Pachymetry
measurements were taken one day prior to lens wear at 4 p.m., on the day of
wear prior to lens application, and after removal of the lenses at 4 p.m.
Measurements were collected using both the Pentacam® HR Corneal
Tomographer, as well as the Visante Anterior Segment Optical Coherence
Tomographer (OCT). The apical clearance was measured using the
Visante OCT at two intervals during the test day: immediately after application of
the lens and immediately prior to the removal of the lens.
Results: In this study, there was found to be no significant difference in corneal
edematous response during lens wear between the two test groups. The study
shows that the eyes with the lenses have a statistically significantly thicker
cornea compared to the non-lens-wearing eye after wearing either lens for 8
hours, lying within clinically and physiologically acceptable limits.
Conclusion: Our clinical results do not correlate with current theoretical
calculations, which predict a greater amount of corneal swelling with increasing
tear layer thickness. It has to be evaluated if the effect on corneal edema
changes with longer wearing periods, larger samples or other influences.
Key words: scleral (contact) lens, corneal edema, pachymetry, tear layer
thickness, vaulting, apical clearance
Purpose
Automated scanpath comparison metrics should deliver an objective method to
evaluate the similarity of scanpaths. The aim of this thesis is an evaluation of
seven existing scanpath comparison metrics in static and dynamic tasks in order
to provide a guidline that helps to decide which algorithm has to be chosen for a
special kind of task.
Methods
The applicability of the algorithms for a static, visual search task and a dynamic,
interactive video game task as well as their constraints and limitations were tested.
Therefore, binocular gaze data were recorded by using the eye tracking system The
Eye Tribe (The Eye Tribe ApS, Copenhagen/ Denmark). Objective task performance
measures from 21 subjects were used in order to create scanpath groupings
for which a relevant effect of dissimilarity was to be expected. Objective task performance
measures such as task performance time were statistically evaluated and
compared to the results gained by the comparison metrics.
Results
Four of the algorithms being used successfully identified differences for static and
dynamic tasks: MultiMatch, iComp, SubsMatch and the Hidden Markov Model.
ScanMatch was very sensitive for the static task but not applicable to the dynamic
task whereas FuncSim was suitable for dynamic but not for static tasks. Eyenalysis
failed to detect any effect.
Conclusion
The applicability of scanpath comparison metrics depends on the state of the task,
respectively on the kind of experimental set up. In future, the application area for
eye tracking will expand and an improvement of automated scanpath comparison
metrics is therefore required.
Purpose
The purpose of this study was to investigate the correlation of measured visual acuity
(VA) both static and dynamic obtained with static and dynamic measuring tests, as well
as, response time to visual stimulus and analysis of its influence on dynamic visual
acuity. The aim was to compare the results gathered for the three age groups and
analyze the possible differences.
Methods
The test groups consisted of 75 subjects between 10 and 60 years old, categorized in
three age groups. The measurements of static and dynamic visual acuity and reaction
time were conducted. The set of nine tests (five with radial magnification speed and four
simulating driving condition at 72 km/h and 130 km/h) was designed in order to measure
dynamic visual acuity and the set of two tests for reaction time measurement.
Results
Compared to static visual acuity in both tests, the results obtained with measurements
of dynamic visual acuity resulted in lower values depending on Landolt ring size and
magnification speed of animation. In average, the dynamic visual acuities in tests with
different magnification speeds were lower than static by 0.4 visual acuity units, or 31%
and the average of dynamic visual acuity after subtracting motoric component (reaction
time) was for 0.2 visual acuity worse than static or 15%. In the second test simulating
driving conditions at 72 km/h the average drop in dynamic visual acuity was 33% while
at 130 km/h average drop for younger and middle age groups was 37% and for older
group was 44% and after subtracting motor component values for 72 km/h speed
simulation average drop in visual acuity values was 23% for all three groups; for 130
km/h speed simulation younger and middle aged group average drop of visual acuity
was 20% and with older group it was 24%.
Conclusion
The tests used in this study were simple and fast and revealed significant difference
between static and dynamic visual acuity and influence of reaction time on dynamic
Nataša Vujko Muždalo Abstract
2
visual acuity values. It is hoped that this thesis will be a positive contribution in testing
and training of dynamic visual and sensory response skill with drivers, sportsmen and
people with visual-motor dysfunction.
Keywords: Dynamic visual acuity (DVA), static visual acuity (SVA), reaction time (RT),
motoric component, dynamic visual acuity test, reaction time test, radial increase in size
Purpose: Usually, a theory of attention upon gazed-at locations is applied. More parameters than gaze location can be derived to improve the theory of attention allocation. The aim of this study was to identify parameters related to eye tracking, that are suitable indicators of attention.
Methods: Binocular eye tracking data was collected with the Eye Tribe tracking system (The Eye Tribe Aps, Copenhagen, Denmark) for the task of visual exploration of the painting “Unexpected Visitors” by Ilya Repin. 20 subjects (valid data: 19/20) had to look at this painting for about two and a half minutes in order to generate fatigue and inattention. In a second step, suitable parameters of attention were transferred to a data set (8 subjects, valid data: 6/8) on a perimetric task executed with the OCTOPUS 900 perimeter (Haag-Streit, Köniz, Switzerland). Monocular parameters could be applied on the perimetric task, the error rate (false positive and false negative catch trials, 5 % each) were taken as additional parameter.
Results: For the image viewing task, the only parameter showing significance was the average level (a10) of fatigue waves (p = 0.00024, ANOVA, ∆ = -0.8316 px). Blink duration (∆ =-270.4 ms), pupil variability (∆ = -0.17868), saccade length (∆ =-0.3135 px) and fixation duration (∆ = 186.5 ms) did not change significantly, but showed relevant trends by differences ∆ of their median between the first and last tenth of the recording time. Blink rate and the Index of Cognitive Activity (ICA) did neither show significant changes nor relevant trends. Vergence accuracy failed to indicate fatigue due to variability between subjects and comparatively small effect size. For the perimetric data, in 3 of 6 subjects fatigue waves over a limited time window could be observed. Only for one subject, a relevant increase in false negative responses to catch trials (50 percentage points) could be observed.
Conclusion: Pupil diameter variability, saccade length, fixation duration and fatigue waves were the parameters indicating fatigue. Only the latter parameter has the potential to be applied to perimetric data.
In der Arbeit wurde eine GC-MS-Methode zur Quantifizierung von 21 identifizierten Aromastoffen, die aus getoasteten Eichenholzchips in Wein übergehen, entwickelt. Diese Methode wurde für die ausgewählten Substanzen unter Einbeziehung der Festphasenextraktion mittels des internen Standard 2-Octanol kalibriert. Die Analyte zeigten mit Ausnahme von Syringaaldehyd lineares Verhalten bei Korrelationen von 0,986 bis 0,999. Die Nachweisgrenzen, die über das Signal-zu-Rausch-Verhältnis ermittelt wurden, lagen im Bereich von 0,03 bis 0,47 µg/l. Der Test auf Wiederholbarkeit ergab mit Werten von kleiner 10% für die meisten untersuchten Stoffe in Rot- und Weißwein zufrieden stellende Werte. Mit der entwickelten Methode wurden Barriqueweine des Handels und selbst hergestellte Chipsweine untersucht. Bei der Untersuchung der Chipsweine, die nach einem vollen Versuchsplan hergestellt wurden, zeigten sich signifikante Einflüsse durch die Faktoren Kontaktzeit, Toastung und Größe sowie durch die Wechselwirkung Toastung-Größe auf die Konzentrationen der meisten identifizierten Substanzen. Bei der Betrachtung der Konzentrationen der ausgewählten Substanzen in Barriqueweinen zeigten sich signifikante Unterschiede zu den entsprechenden Konzentrationen in den hergestellten Chipsweinen. Diese signifikanten Unterschiede wurden mittels Hauptkomponentenanalyse und anschließender Klassifizierung über die SIMCA-Methode dazu genutzt, um die önolgischen Verfahren Chipsbehandlung und Barriquefasslagerung zu differenzieren.